| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method for synthesis of hetaryl derivatives of 2-nitro-2-(3-phenyl-1,2,4-oxadiazol-5-yl)-ethanes of general formula where, I a,d,i R1=NO2, R2=H; I b,e,k R1=NO2, R2=Me; I v,g,l R1=CO2Et, R2=H; I e,z,m R1=CO2Et, R2=Me; I a-r R3=piperidinyl; I d-z R3=1-pyrrolidinyl, I i-m R3=morpholinyl, based on a nucleophilic substitution reaction of terminal chlorine in 2-nitro-1-chloro-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanes of formula IV with 2,5 times excess piperdine, pyrrolidine or morpholine, while heating and stirring in dried ethanol and holding at temperature 25C for 2 days. ^ EFFECT: efficient method of producing hetaryl derivatives. ^ 1 cl, 2 tbl, 12 ex |
