发明名称 |
BISPHOSPHONATE-PROSTATIC ACID PHOSPHATASE INHIBITOR CONJUGATES TO TREAT PROSTATE CANCER BONE METASTASIS |
摘要 |
The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid. |
申请公布号 |
CA2812158(A1) |
申请公布日期 |
2011.03.24 |
申请号 |
CA20102812158 |
申请日期 |
2010.09.16 |
申请人 |
MOUNT SINAI SCHOOL OF MEDECINE;LEHIGH UNIVERSITY |
发明人 |
KIRSCHENBAUM, ALEXANDER;LEVINE, ALICE C.;REGEN, STEVEN L.;JANOUT, VACLAV |
分类号 |
A01N57/00;A61K31/663;A61K47/48;A61P35/00 |
主分类号 |
A01N57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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