STABLE NON-CRYSTALLINE FORMULATION COMPRISING HMG-CoA REDUCTASE INHIBITOR

摘要

One or more embodiments of the present invention relate to a formulation comprising an HMG- CoA reductase inhibitor, to co-formulations of HMG-CoA reductase inhibitors with excipients, to methods for preparing the formulations, pharmaceutical compositions comprising the formulations and to their use in medical treatment. Also provided are stable oral pharmaceutical formulations comprising HMG-CoA reductase inhibitors such as atorvastatin, an associated methods for their preparation and use of (administering) the stable oral pharmaceutical formulations and co-formulations. The formulations which result in desired, especially improved or enhanced, solubility or dissolution characteristics, resulting in desired, especially improved or enhanced, bioavailability and/or pharmacokinetics.