CRYSTAL STRUCTURE

摘要

The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of lhe adenosine A2A receptor structure listed in Table (i) or Table (ii), optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.285 A, or selected coordinates thereof; and predicting the three-dimensional structural representation of the target protein, or part thereof, by modelling the structural representation on all or the selected coordinates of the adenosine A2A receptor. The invention also provides the use of the adenosine A2A receptor coordinates to select or design one or more binding partners of adenosine A2A receptor.