METHOD OF ANALYZING SULFATED POLYSACCHARIDE OR SULFATED OLIGOSACCHARIDE, PHARMACEUTICAL COMPOSITION AND DRUG CONTAINING SULFATED POLYSACCHARIDE OR SULFATED OLIGOSACCHARIDE, METHOD OF PRODUCING THE PHARMACEUTICAL COMPOSITION AND THE DRUG, AND METHOD OF TREATING, DIAGNOSING, SYMPTOM-RELIEVING AND PREVENTING DISEASE

摘要

PROBLEM TO BE SOLVED: To provide: an analytical method of highly sensitively analyzing the structure of a sulfated polysaccharide or a sulfated oligosaccharide; a pharmaceutical composition and a drug containing a sulfated polysaccharide or a sulfated oligosaccharide having an excellent biological activity; a method of producing a pharmaceutical composition and a drug; and a method of treating, diagnosing, symptom-relieving and preventing a disease. SOLUTION: A sulfated polysaccharide or a sulfated oligosaccharide is enzymatically digested, and the obtained product containing a monosaccharide, a disaccharide or a trisaccharide is analyzed by mass spectrometry. Thus, the structure of the sulfated polysaccharide or the sulfated oligosaccharide is analyzed and its qualities such as a biological activity are evaluated, which enables production of an excellent pharmaceutical composition or drug. The pharmaceutical composition and drug have excellent biological activities relating to the tumor metastasis inhibitory activity, dengue virus-infection inhibitory activity, growth factor-binding activity and so on of chondroitin sulfate. COPYRIGHT: (C)2011,JPO&INPIT