发明名称 |
SYNERGISTIC ANTI-CD47 THERAPY FOR HEMATOLOGIC CANCERS |
摘要 |
Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden. The combination of antibodies may comprise a plurality of monospecific antibodies, or a bispecific or multispecific antibody. Markers of interest include without limitation, CD20, CD22, CD52, CD33; CD96; CD44; CD123; CD97; CD99; PTHR2; and HAVCR2. |
申请公布号 |
WO2011034969(A1) |
申请公布日期 |
2011.03.24 |
申请号 |
WO2010US48992 |
申请日期 |
2010.09.15 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;WEISSMAN, IRVING L.;MAJETI, RAVINDRA;ALIZADEH, ARASH ASH;CHAO, MARK P. |
发明人 |
WEISSMAN, IRVING L.;MAJETI, RAVINDRA;ALIZADEH, ARASH ASH;CHAO, MARK P. |
分类号 |
A61K39/00;C12P21/08 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|