发明名称 |
PHOTOCHEMICAL INTERNALISATION OF KINASE INHIBITORS |
摘要 |
<p>The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photosensitizing agent and irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and to the use of this method for enhancing the effects of kinase inhibitors or kinase inhibitor-based drugs in particular to achieve cell death, for example, in cancer treatment and other diseases or conditions in which kinase inhibitors, such as TKIs, have a beneficial effect.</p> |
申请公布号 |
EP2296706(A2) |
申请公布日期 |
2011.03.23 |
申请号 |
EP20090772782 |
申请日期 |
2009.06.26 |
申请人 |
PCI BIOTECH AS |
发明人 |
HOEGSET, ANDERS;WEYERGANG, ANETTE;SELBO, PAAL, KRISTIAN;BERG, KRISTIAN |
分类号 |
A61K41/00;A61K31/00;A61P35/00;A61P43/00 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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