发明名称 |
H3LMN COMPOUND USED AS RADIOACTIVE AGENT FOR TREATMENT OF LIVER CANCER AND MANUFACTURING METHOD THEREOF |
摘要 |
H3LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for protection of thiol to obtain 2-[(triphenylmethyl)thio]ethylamine. Then obtain N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide by a transamidation reaction between 2-[(triphenylmethyl)thio]ethylamine and chloroactyl chloride. Next produce a amine-amide-thiol ligand-N-[2-((triphenylmethyl)thio)ethyl][2-((triphenylmethyl)thio)ethylamino]acetamide by a substitution reaction of N-[2-((triphenylmethyl)thio)ethyl]chloroacetamide and 2-[(triphenylmethyl)thio]ethylamine. After respective reaction with 1-bromotetradecane, 1-bromohexadecane and ethyl 16-bromohexadecanoate, H3LMN series compounds are obtained. These amine-amide-dithiols quadridentate ligands can react with MO3+ (M=Tc or Re) to produce electrically neutral complexes. The complexes have high lipophilicity, allowing them soluble in lipiodol to be applied to radiation therapy for liver cancer.
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申请公布号 |
US2011065904(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20090558911 |
申请日期 |
2009.09.14 |
申请人 |
LIU SHOW-WEN;LIN CHENG-HSIEN;LIN TSYH-LANG;HSU CHENG-FANG |
发明人 |
LIU SHOW-WEN;LIN CHENG-HSIEN;LIN TSYH-LANG;HSU CHENG-FANG |
分类号 |
C07F13/00;C07C69/003;C07C237/04 |
主分类号 |
C07F13/00 |
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