INTRAPERICARDIAL DELIVERY OF PERIOSTIN

摘要

Compositions and methods for delivery of periostin or fragments or variants thereof to or near the pericardial space are provided. In some embodiments, a sustained release vehicle is used to deliver periostin or fragments or variants thereof in a controlled manner to treat the heart of a subject. The sustained release vehicle may be, for example, a hydrogel particle. In certain embodiments, compositions and methods are provided for inhibiting formation of tissue adhesions within the pericardial space.