发明名称 |
METHODS AND COMPOSITIONS INVOLVING CHITOSAN NANOPARTICLES |
摘要 |
Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the weight ratio of the chitosan to the polyphosphate is about 1.0 or greater and the weight ratio of the polyphosphate to the therapeutic agent or diagnostic agent is about 15.0 or less. Also disclosed are nanoparticles that include a chitosan and an inhibitor of enhancer of Zeste homologue 2 (EZH2). Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease and methods of predicting prognosis of ovarian cancer in a subject that involve determining the expression and/or function of EZH2 in the subject are also disclosed.
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申请公布号 |
US2011064664(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20080680728 |
申请日期 |
2008.10.08 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
LOPEZ-BERESTEIN GABRIEL;OZTURK EYLEM;SANGUINO ANGELA;SOOD ANIL;DENKBAS EMIR BAKI |
分类号 |
A61K49/00;A61K31/7052;A61K38/02;A61K39/395;A61K47/30;A61P35/00;C12Q1/68;C40B30/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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