发明名称 |
Artificially synthesized peptide |
摘要 |
A short synthetic vector peptide of 25 residues has been developed comprising hydrophobic domain and a novel, nuclear localization signal for efficient delivery, devoid of any cytotoxicity. Using the vector peptide, the oligonucleotide/peptide complexes got delivered evenly in cytoplasm and nucleus in less than an hour and finally localizing completely into nucleus in two hours and protein (antibody) to cytoplasm within 1 hour in both primary (chicken embryo fibroblast) cells and established mammalian cell line (Vero cells).
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申请公布号 |
US2011065175(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20060311554 |
申请日期 |
2006.10.06 |
申请人 |
INDIAN COUNCIL OF AGRICULTURAL RESEARCH |
发明人 |
KUMAR SATISH;BAIS MANISH VIRENDRASINGH;KATARIA RANJIT SINGH;YADAV MAHENDRA PAL |
分类号 |
C12N5/00;C07K14/00;C12N15/63 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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