JMJD2 DEMETHYLASE INHIBITORS

摘要

The present invention relates to inhibitors of JMJD2 subfamily histone lysyl demethylase enzymes. In particular, the invention relates to compounds that are capable of inhibiting a JMJD2 subfamily histone lysyl demethylase without also inhibiting a 2-oxoglutarate dependent oxygenase that is not a JMJD2 subfamily histone lysyl demethylase, and to assays for the identification of inhibitors of JMJD2 subfamily histone lysyl demethylase enzymes.