摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to compounds of general formula in which R1 stands for C1-C4-alkyl; R2 stands for C1-C4-alkyl; R3 stands for phenyl, which optionally contains 1-3 any substituents, selected from the group, including halogen, C1-C6-alkyl and C1-C4-alkoxygroup; R4 stands for hydrogen; C1-C6-alkyl or C3-C7-cycloalkyl -C1-C4-alkyl, R5 stands for hydrogen; and R6stands for hydrogen; and R7 stands for hydrogen; and R9 stands for C1-C4-alkyl; and R10 stands for C1-C6-alkyl, phenyl-C0-C4-alkyl or pyridinyl-C0-C4-alkyl; on condition that R10 does not stand for phenyl, if R5 and R9 together form C2-alkylene; or R5 R9 together form C1-C3-alkylene; or R6 and R9 together form C1-C3-alkylene; or R7 and R9 together form C2-C4-alkylene or C1-C3-alkyleneoxygroup; or R8 and R9 together form C3-C5-alkylene; or R9 and R10 together form C4-C6-alkylene; and n equals 0 or 1, or its any physiologically compatible salts. In addition, the invention relates to pharmaceutical composition, containing formula I compounds and intended for treatment of cardio-vascular diseases, to application of said compounds for preparation of medication, as well as to method of obtaining formula I compounds. ^ EFFECT: obtained and described are novel compounds, possessing cardio-vascular activity. ^ 16 cl, 8 ex, 5 tbl |