| 发明名称 |
PAKs as Modifiers of the CHK Pathway and Methods of Use |
| 摘要 |
Human PAK genes are identified as modulators of the CHK pathway, and thus are therapeutic targets for disorders associated with defective CHK function. Methods for identifying modulators of CHK, comprising screening for agents that modulate the activity of PAK are provided.
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| 申请公布号 |
US2011059066(A1) |
申请公布日期 |
2011.03.10 |
| 申请号 |
US20100828515 |
申请日期 |
2010.07.01 |
| 申请人 |
EXELIXIS, INC. |
发明人 |
FRANCIS-LANG HELEN;ROCHE SIOBHAN;KIM LICKTEIG |
| 分类号 |
A61K39/395;G01N33/50;A61K39/00;A61K45/00;A61K49/00;A61P9/00;A61P35/00;A61P43/00;C12N5/02;C12N15/09;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/15;G01N33/573 |
主分类号 |
A61K39/395 |
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