发明名称 |
Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods |
摘要 |
Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided.
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申请公布号 |
US7901690(B2) |
申请公布日期 |
2011.03.08 |
申请号 |
US20030728195 |
申请日期 |
2003.12.03 |
申请人 |
UNIVERSITY OF MASSACHUSETTS;ADVANCED BIOSCIENCE LABORATORIES |
发明人 |
LU SHAN;WANG SHIXIA;PAL RANAJIT;KALYANARAMAN VANIAMBADI;WHITNEY STEPHEN CHARLES;KEEN TIM;NAIR BALACHANDRAN;MARKHAM PHILLIP |
分类号 |
A61K39/21;A61K39/00;A61K39/295;C07K14/16;C12N15/00 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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地址 |
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