SURFACE-MODIFIED LAYERED GADOLINIUM HYDROXIDE, PROCESS OF PREPARING THE SAME AND MRI CONTRAST AGENT INCLUDING THE SAME

摘要

PURPOSE: A surface-modified layered gadolinium hydroxide is provided to exfoliate layers by surface-modifying the layers, to improve biocompatibility of LGdH, and to enhance resistance to acids. CONSTITUTION: A surface-modified layered gadolinium hydroxide of chemical formula (I): Gd2(OH)5X·nH2O is surface modified with phospholipid having a poly(ethylene glycol)(PEG) terminal group. A method for preparing the surface-modified layered gadolinium hydroxide of chemical formula (I); reacting LGdH of chemical formula (II):n Gd2(OH)5Y·nH2O with fatty acid salts to obtain exfoliated layered gadolinium hydroxide of chemical formula (I); and deforming the exfoliated layered gadolinium hydroxide with phospholipids having a poly(ethylene glycol)(PEG) terminal group.