PROCESS FOR THE PRECIPITATION OF INHALABLE PHARMACEUTICAL AGENTS IN THE PROPELLANT

摘要

A process for providing a dispersion of a pharmaceutical product in a liquefied gas propellant in a metered dose inhaler comprising preparing a supercritical solution of the pharmaceutical product dissolved in the propellant in a supercritical fluid state then reducing the temperature and pressure of the supercritical solution to respectively below T c and below p c to precipitate the pharmaceutical product and provide a dispersion of the pharmaceutical product in the liquefied propellant; then charging the dispersion to the canister of an MDI.