METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF BETA-GLUCOCEREBROSIDASE

摘要

Provided is a method of increasing the stability of wild-type &bgr;-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual having a neurological disease in which increased expression or activity of &bgr;-glucocerebrosidase in the central nervous system would be beneficial. This method comprises administering an effective amount of a pharmacologic chaperone for &bgr;-glucocerebrosidase, with the proviso that the individual does not have a mutation in the gene encoding &bgr;-glucocerebrosidase. Further provided are &bgr;-glucocerebrosidase inhibitors which have been identified as specific pharmacologic chaperones and which have been shown to increase activity of &bgr;-glucocerebrosidase in vivo in the central nervous system.