发明名称 |
NUCLEIC ACID COMPOUNDS FOR INHIBITING GENE EXPRESSION AND USES THEREOF |
摘要 |
The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), and blunt ended double-stranded ribonucleic acid molecules capable of decreasing or silencing expression of a target gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a target mRNA. Also provided are methods of decreasing expression of a target gene in a cell or in a subject to treat a disease or condition associated with the target gene.
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申请公布号 |
CA2677068(A1) |
申请公布日期 |
2011.03.01 |
申请号 |
CA20092677068 |
申请日期 |
2009.09.01 |
申请人 |
MDRNA, INC. |
发明人 |
QUAY, STEVEN C.;MCSWIGGEN, JAMES;VAISH, NARENDRA K.;AHMADIAN, MOHAMMAD |
分类号 |
C12N15/11;A61K31/7105;A61K31/713;A61K48/00;A61P29/00;A61P35/00;C07H21/02 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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