| 摘要 |
THE SUBJECT INVENTION PROVIDES A COMPOUND ACCORDING TO FORMULA 1, WHEREIN IS O, NOH, NO(1-4C)ALKYL, NO(1-4C)ACYL; A1-A5 ARE C, SUBSTITUTED WITH R1, OR N, PROVIDED THAT AT LEAST ONE AND NOT MORE THAN THREE OF A1 -A5 ARE N; OR ONE OR TWO OF A1, A2 AND A5 ARE N, AND THE OTHERS ARE C, SUBSTITUTED WITH R1, AND A3 AND A4 TOGETHER REPRESENT A FUSED BENZO RING OR A FUSED FIVE- OR SIX-MEMBERED NITROGEN-CONTAINING AROMATIC RING, BOTH OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN AND/OR (1-4C)ALKYL; R1 IS H, HALOGEN, (1 -4C)ALKYL, (1 -4C)ALKOXY; R2 IS H, (1 -4C)ALKYL OR (1 -6C)ALKENYL, BOTH OPTIONALLY SUBSTITUTED WITH AN (6-1 O)ARYL GROUP, WHICH IS OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN AND/OR (1-4C)ALKYL; AND R3 IS H OR (1-4C)ALKYL, OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN ATOMS; AND R4 IS CYCLOPROPYL OR CYCLOPROPENYL, BOTH OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN AND/OR (1 -4C)ALKYL; OR R2 TOGETHER WITH R3 FORMS A 3-, 4-, 5- OR 6- MEMBERED CARBOCYCLIC RING; AND R4 IS CYCLOPROPYL OR CYCLOPROPENYL, BOTH OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN AND/OR (1 -4C)ALKYL); OR R2 IS H OR (1 -4C)ALKYL; AND R3 TOGETHER WITH R4 FORMS A 5-, 6- OR 7-MEMBERED SATURATED OR UNSATURATED CARBOCYCLIC RING; R5 IS H OR (1 -4C)ALLCYL; OR A PHARMACEUTICALLY ACCEPTABLE SALT AND/OR HYDRATE FORM AND/OR PRODRUG THEREOF.
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