Dried and/or microencapsulated saccharomyces cerevisiae cells with a high content of (S)-(+)-S-adenosyl-L-methionine, process for their preparation, and compositions containing said cells

摘要

Disclosed is a pharmaceutical composition (such as a tablet, a gastroresistant tablet or a capsule) containing: (a) dried and/or microencapsulated Saccharomyces cerevisiae cells wherein (R)-(+)-(S)-adenosyl-L-methionine is in a quantity lower than or equal to 10% of (S)-(+)-S-adenosyl-L-methionine, said (S)-(+)-adenosyl-L-methionine being in the form of a free base obtainable from strains of Saccharomyces cerevisiae having a (S)-(+)-S-adenosyl-L-methionine productivity of 2.0-6.0% w/dry w at the end of fermentation and 7-20% w/dry w at the end of an enrichment stage, and (b) suitable excipients, in dried form or in microencapsulated form.