发明名称 |
DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF |
摘要 |
The invention relates to cell lines from differentiated cells with hepatocytic phenotypes capable of producing albumin and blood coagulation factors, said cells being derived from a human leukaemia cell line, preferably the human THP1 cell line, and preserving the characteristics of immortality. Among the cell lines of the invention, the cell lines known as PSC-THP1-EP, PSC-THP1-EP-FAST, PSC-THP1-HEP and PSC-THP1-EPEP are preferred. The invention also relates to methods for obtaining the cell lines of the invention and the uses of said cell lines, particularly for the production of albumin and/or blood coagulation factors.
|
申请公布号 |
US2011045519(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
US20070521517 |
申请日期 |
2007.12.21 |
申请人 |
GENNERO LUISA;PONZETTO ANTONIO;PESCARMONA GIAMPIERO;SAVARINO ANDREA;MERIZZI GIANFRANCO |
发明人 |
GENNERO LUISA;PONZETTO ANTONIO;PESCARMONA GIAMPIERO;SAVARINO ANDREA;MERIZZI GIANFRANCO |
分类号 |
C12N5/071;C12N5/09;C12N5/22;C12P21/00;C12Q1/02 |
主分类号 |
C12N5/071 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|