DIAGNOSING AND MANAGING VENOUS THROMBOEMBOLISM AND INTRACARDIAC THROMBI USING A PROVOKED D-DIMER TEST
摘要
<p>The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention comprises the steps of: obtaining a plasma sample from said individual; determining the baseline level of D-dimer in said sample; contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin; and measuring the level of D-dimer is said sample after administering or contacting said sample with a compound that catalyzes the conversion of plasminogen into plasmin, wherein a significantly greater concentration of D-dimer after contact with a compound that catalyzes the conversion of plasminogen into plasmin than prior to contact with a compound that catalyzes the conversion of plasminogen into plasmin indicates that said individual has pulmonary embolism or venous thromboembolism.</p>
申请公布号
WO2011022054(A2)
申请公布日期
2011.02.24
申请号
WO2010US02265
申请日期
2010.08.18
申请人
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC.;ROBINSON, VINCENT, J., B.