发明名称 |
Protein involved in G protein-coupled receptor mediated signal transduction with ability to mediate signal transduction from a dopamine D1 receptor or an adenosine A2A receptor to an adenylate cyclase and utilization thereof |
摘要 |
A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein α subunits and a trimer forming domain conserved among G protein α subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.
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申请公布号 |
US7893203(B2) |
申请公布日期 |
2011.02.22 |
申请号 |
US20080118247 |
申请日期 |
2008.05.09 |
申请人 |
SUMITOMO CHEMICAL COMPANY, LTD. |
发明人 |
TAKAHASHI YASUHIKO;MATSUMOTO YASUO;OEDA KENJI |
分类号 |
C07K14/47;C07K14/705 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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