发明名称 DERIVATIVES OF 1,1-DIOXOTHIOMORPHOLINYLINDOLYL METHANONE FOR USE AS HISTAMINASE MODULATORS
摘要 FIELD: chemistry. ^ SUBSTANCE: invention describes compounds of formula I ^ , where R1 is selected from a group comprising hydrogen, lower alkyl, lower hydroxyl, lower alkoxyalkyl, lower halogenalkyl, lower cyanoalkyl; unsubstituted or substituted phenyl; lower phenylalkyl, where the phenyl ring can be unsubstituted or substituted; and heteroaryl, selected from pyridyl and pyrimidinyl; R2 denotes hydrogen or halogen; G denotes a group selected from ^ , where m equals, 0, 1; R3 is selected from lower alkyl, cycloalkyl and lower cycloalkylalkyl; n equals 0, 1; R4 denotes lower alkyl, as well as pharmaceutical compositions. ^ EFFECT: said compounds are used to treat or prevent diseases associated with histaminase receptor modulation. ^ 19 cl, 1 tbl, 24 ex
申请公布号 RU2412182(C2) 申请公布日期 2011.02.20
申请号 RU20080126389 申请日期 2006.11.20
申请人 F.KHOFFMANN-LJA ROSH AG 发明人 NETTEKOVEN MATTIAS;PLANSHE ZHAN-MARK;RIKHTER KHANS;ROSHE OLIV'E;RODRIGES-SARM'ENTO ROSA-MARIJA;TAJLOR SVEN
分类号 A61K31/404;A61K31/445;A61K31/54;A61P3/04;C07D401/12;C07D401/14;C07D403/12;C07D403/14;C07D417/12;C07D417/14 主分类号 A61K31/404
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