发明名称 |
VERFAHREN ZUR PRÄVENTION VON TUMORREZIDIVEN DURCH BLOCKADE VON TGF-BETA |
摘要 |
<p>Methods are provided herein to prevent a tumor recurrence in a subject, involving administering to the subject an agent that blocks the TGF-beta signaling pathway. In one embodiment, the agent inhibits the immunosuppressive effects of TGF-beta. Also provided is a method of enhancing an immune respond in a subject to inhibit recurrence of a tumor by administering an agent which blocks the TGF-beta signaling pathway. A method of enhancing the activity of an immune cell to inhibit recurrence of a tumor by contacting a TGF-beta receptor-expressing cell with an agent which blocks the TGF-beta signaling pathway is also provided, as are methods of screening for an agent that inhibits or measurably reduces the recurrence of a tumor.</p> |
申请公布号 |
AT496066(T) |
申请公布日期 |
2011.02.15 |
申请号 |
AT20030779310T |
申请日期 |
2003.10.24 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BERZOFSKY, JAY;TERABE, MASAKI;MATSUI, SO |
分类号 |
C07K16/22;A61K38/00;A61K39/395;G01N33/50 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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