| 摘要 |
The present invention is directed to binding proteins derived from the protein superfamily of ubiquitin like proteins with modifications in their alpha helical region. The present invention is further directed to a method for the generation of those proteins as well as to a protein obtainable by said method. Furthermore, the invention provides the use of a protein for the specific recognition, binding and neutralization of a predescribed target molecule, for the detection, quantitative determination, separation and/or for the isolation of a corresponding binding partner and the use of a protein of the invention, for diagnosis, prophylaxis and treatment of diseases in which the corresponding binding partner is directly or indirectly involved. |
