发明名称 |
Inhibitors of P38 Map Kinase |
摘要 |
Compounds of formula (I) are p38 MAP kinase inhibitors useful for the treatment of autoimmune and inflammatory diseases: wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted CrC3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula (IA); wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z is O or 1; —X1-L1-Y— is a linker radical or bond; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 and R3 are as defined in the claims.
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申请公布号 |
US2011034520(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
US20090867774 |
申请日期 |
2009.02.27 |
申请人 |
MOFFAT DAVID FESTUS CHARLES;DAVIES STEPHEN JOHN;PINTAT STEPHANE |
发明人 |
MOFFAT DAVID FESTUS CHARLES;DAVIES STEPHEN JOHN;PINTAT STEPHANE |
分类号 |
A61K31/4418;A61P3/10;A61P11/00;A61P11/06;A61P17/00;A61P29/00;A61P37/06;C07D213/73 |
主分类号 |
A61K31/4418 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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