发明名称 |
POST RELEASE MODIFICATION OF VIRAL ENVELOPES |
摘要 |
The present invention relates to enveloped virus particles providing a modified composition of their envelope, methods for exogenously modifying the envelope composition of an enveloped viral particle making use of compounds consisting of a hydrophilic target domain and a lipophilic membrane anchor domain, wherein the lipophilic membrane anchor domain becomes anchored into the lipid double layer of the envelope and wherein the hydrophilic target domain becomes exposed to the surrounding incubation fluid. The invention further relates to methods and means to use said modified viral vectors and to pharmaceutical compositions containing such envelope modified viral vectors. |
申请公布号 |
EP2281033(A1) |
申请公布日期 |
2011.02.09 |
申请号 |
EP20090732768 |
申请日期 |
2009.04.03 |
申请人 |
GUENZBURG, WALTER |
发明人 |
DANGERFIELD, JOHN;METZNER, CHRISTOPH |
分类号 |
C12N7/00;A61K39/00;A61K48/00 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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