发明名称 |
Racemization and Enantiomer Separation of Clopidogrel |
摘要 |
<p>Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.</p> |
申请公布号 |
EP2168969(A3) |
申请公布日期 |
2011.02.09 |
申请号 |
EP20090171852 |
申请日期 |
2002.11.22 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
MERLI, VALERIANO;DAVERIO, PAOLA;BIANCHI, STEFANO |
分类号 |
C07D495/04;A61K31/4365;A61K31/4743;A61P9/00;C07D513/04 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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