发明名称 |
ANTIBIOTIC 107891, ITS FACTORS A1 AND A2, PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOSITIONS, AND USE THEREOF |
摘要 |
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors Al and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors Al and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and van comycin resistant strains, and is active also against some Gram-negative bacteria suchas M. catharralis, Neisseria species and H. influenzaeand Mycobacteria. |
申请公布号 |
CA2529124(C) |
申请公布日期 |
2011.02.08 |
申请号 |
CA20042529124 |
申请日期 |
2004.07.12 |
申请人 |
VICURON PHARMACEUTICALS INC. |
发明人 |
LAZZARINI, AMERIGA;GASTALDO, LUCIANO;CANDIANI, GIANPAOLO;CICILIATO, ISMAELA;LOSI, DANIELE;MARINELLI, FLAVIA;SELVA, ENRICO;PARENTI, FRANCO |
分类号 |
C07K14/195;A23K20/195;A61K38/00;A61K38/02;A61K38/16;A61P31/04;C07K1/14;C07K2/00;C07K14/37;C12P1/06;C12P21/02 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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