METHODS AND COMPOSITIONS FOR THE INHIBITION OF VIRAL INFECTION BY TARGETING INTRACELLULAR TRAFFICKING

摘要

The present invention features methods and compositions for the treatment or inhibition of infection by human papillomavirus (HPV) in a subject by administering an agent (e.g., a small molecule or antibody) that binds the carboxy-terminal region of the HPV L2 protein and reduces or inhibits the binding of the L2 protein to an intracellular molecular motor protein (IMMP) or IMMP co-factor. The invention also features a method for treating or inhibiting an HPV infection by administering a nucleic acid molecule that, for example, decreases the expression of the HPV L2 protein.