发明名称 |
TRANSCRIPTION FACTOR ARNTL2 GENE AND EXPRESSION PRODUCTS THEREOF USED IN THE DIAGNOSIS, PREVENTION, AND TREATMENT OF TYPE 1 DIABETES |
摘要 |
The present application identifies the involvement of the HIFbeta-homologous Arntl2 gene in the control of type 1 (insulin-dependent) diabetes. Accordingly, the present invention provides a method of determining the susceptibility of a subject to developing insulin-dependent diabetes based on the expressing level of the Arntl2 gene. The present invention also provides a method for identifying compounds effective for treating or preventing insulin-dependent diabetes in a subject in need thereof and a method of treating or preventing insulin-dependent diabetes by administering an effective amount of compound identified by the identification method. The present invention also provides a method of enhancing protection against insulitis progression or autoimmune diabetes development in a subject in need thereof comprising, enhancing expression of the Arntl2 gene or modulating the expression of target genes thereof. |
申请公布号 |
HK1126251(A1) |
申请公布日期 |
2011.02.02 |
申请号 |
HK20090104802 |
申请日期 |
2009.05.26 |
申请人 |
INSTITUT PASTEUR |
发明人 |
AVNER, PHILIP;ROGNER, UTE, CHRISTINE;HUNG, MING-SHIU |
分类号 |
C12Q;G01N |
主分类号 |
C12Q |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|