| 摘要 |
<p>The invention concerns compounds of general formula (I) in which: R1 represents a hydrogen atom or a C¿1?-C6 alkyl group, linear or branched; R2 represents a hydrogen atom, a C1-C6 alkyl group linear or branched, a halogen atom, a C1-C6 alkoxy group, linear or branched or C1-C6 trihalogenoalkyl group, linear or branched; X represents a hydrogen atom; Y represents a hydrogen atom or a hydroxyl group, or X and Y together form an oxo group; Z represents an oxygen atom or a sulphur atom; Ar represents an aromatic group selected among phenyl, naphthyl, substituted phenyl, substituted naphthyl or a heterocyclic group selected among pyridyl, pyrazinyl, pyrimidinyl, indolyl, quinolyl, pyrrolyl, thienyl, benzothienyl, furyl, each of these heterocyclic groups being optionally substituted, their geometrical and/or optical isomers, and their additive salts to a pharmaceutically acceptable acid or base. The compounds have particularly interesting peripheral analgesic therapeutic properties.</p> |
