1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them

摘要

Disclosed is an imidazoles derivative of formula (I), or an acid addition salt or stereoisomer thereof, wherein R1 and R2 are each hydrogen or alkyl, Q is a bond, C(O), SO2, CONH, C(O)(CH2)n, (CH2)nO or (CH2)n, where n is 0-2, Z is selected from the three pictured ring systems, and the rest of the substituents and variables are as defined in the specification. This derivative inhibits aromatase, steroid sulfatase, and carbonic anhydrase. Disclosed is its use to treat hormone-or non hormone-dependent tumors, benign or malignant diseases of the breast, the uterus or the ovary, androgen-dependent diseases or benign or malignant diseases of the prostate or the testis, cognitive function disorders, especially senile dementia, Alzheimer's disease, and immunodisorders, and also for the control or management of reproductive functions.