Benzotriazine inhibitors of kinases

摘要

Disclosed are 3-aminoarylene-1,2,4-benzotriazine derivatives of the general formula (I), which are useful compounds for the treatment of disorders associated with compromised vasculostasis (such as myocardial infarction, stroke, congestive heart failure, an ischemia or reperfusion injury, cancer, arthritis or other arthropathy, retinopathy or vitreoretinal disease, macular degeneration, autoimmune disease, vascular leakage syndrome, inflammatory disease, edema, transplant rejection, bum, or acute respiratory distress syndrome (ARDS)), wherein each of A is independently selected from a group consisting of C, CH, N, and a part of a ring fusion to form a second ring, where the second ring is an aromatic, a heteroaromatic, a bicyclic aromatic, a bicyclic aromatic heterocyclic ring, or a bicyclic with only the first ring being aromatic or heteroaromatic; each of B is independently selected from a group consisting of C, CH, N, and a part of a ring fusion to form a second ring, where the second ring is an aromatic, a heteroaromatic, a bicyclic aromatic, a bicyclic aromatic heterocyclic ring, or a bicyclic with only the first ring being aromatic or heteroaromatic; and wherein the other substituents are as defined herein.