Inhibitors of the Interaction Between HMGB Polypeptides and Toll-Like Receptor 2 as Anti-Inflammatory Agents

摘要

The invention features a method of treating an inflammatory condition in an individual, comprising administering an agent inhibits the interaction between a Toll-like receptor 2 (TLR2) and a high mobility group B (HMGB) polypeptide to the individual. The invention also features methods for identifying agents that inhibit the interaction between TLR2 and HMGB.