PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING DISEASES CAUSED BY THE TRANSLOCATION OF GSK3 FROM THE CELL NUCLEUS TO THE CYTOPLASM, CONTAINING COMPOUNDS FOR INHIBITING THE TRANSLOCATION OF GSK3 FROM THE CELL NUCLEUS TO THE CYTOPLASM

摘要

The present invention relates to pharmaceutical compositions for treating or preventing diseases caused by the translocation of GSK3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of GSK3 from the cell nucleus to the cytoplasm. More particularly, the present invention relates to pharmaceutical compositions for inhibiting the growth or the metastatis of cancer cells and pharmaceutical compositions for treating autoimmune diseases, containing novel compounds for inhibiting the translocation of GSK3 from the cell nucleus to the cytoplasm. The present invention provides compositions for inhibiting the outbreak and progression of diseases caused by a decrease in the concentration of GSK3 in the nucleus and the translocation of GSK from the cell nucleus to the cytoplasm. The compounds according to the present invention inhibit the nuclear export function of GSK3 performed by Axin, and increase the concentration of GSK3 in the nucleus, and can thus be valuably used in treating or preventing a variety of diseases caused by a decrease in the concentration of GSK3 in the nucleus.