PROCESS FOR PREPARATION OF LANSOPRAZOLE

摘要

The present invention provides a process for the preparation of Lansoprazole comprising the steps of oxidizing 2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridinyl]methyl]thio]-lH- benzimidazole with an oxidizing agent, washing the reaction mass with aqueous solution of buffer, alkali bicarbonate & alkali thiosulphate, Isolation of product by cooling to low temperature in presence of water, base, amide or mixture thereof. Slurry/crystallizing from water immiscible organic solvent in presence of water, base, amide or mixture thereof. Slurry the product with sodium bicarbonate solution followed by drying yields Lansoprazole.