发明名称 |
GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS |
摘要 |
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence involved in tumor suppression and the nucleic acids encoding the zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression.
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申请公布号 |
US2011023149(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20100842978 |
申请日期 |
2010.07.23 |
申请人 |
SIGMA-ALDRICH CO. |
发明人 |
WEINSTEIN EDWARD;CUI XIAOXIA;SIMMONS PHIL |
分类号 |
A61K49/00;A01K67/027;A61P43/00;C07H21/04;C12N5/10;C12N9/16 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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