| 摘要 |
PURPOSE: Provided is a protein chip for early diagnosis of osteoporosis including its existence, progressive state and its cause by attaching a monoclonal antibody for the various bone metabolism indicators related to the bone turnover process such as bone formation and bone resorption. CONSTITUTION: The measurement of each bone metabolism indicators comprises: attaching protein chips of monoclonal antibody on a base plate which is made of polystyrene, polyvinylchloride, polypropylene or glass; preparing the standard concentration curve by reacting antigen in various concentration with the above monoclonal antibody such as bone specific alkaline phosphatase, osteopontin, osteocalcin, calcitonin, osteoclastogenesis inhibitory factor, osteoprotegerin, TGF B3, calvindin, N-telopeptides, C -telopeptides, free pyridinoline and free deoxypyridinoline; and carrying out the concentration measurement of the bone metabolism indicators in th test sample for diagnosis.
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