| 摘要 |
A conjugate between an anti-thrombotic agent and bioabsorbable polymer includes first or sub-layer which is prepared by mixing polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprises an anti-thrombotic heparin-bioabsorbable polymer conjugate. This coating may be applied over inner drug-containing layers using, for example, dip coating or spray coating processes. After drying, the anti-thrombotic heparin bioabsorbable polymer conjugate remains in the outer layer of coating, allowing agent from the inner layer to elute through the coating. The outmost layer prevents thrombosis, and can modulate release kinetics of agcnt(s) contained within inner laycr(s) of the coating. |
