N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE BUTYRATE, METHOD OF PREPARING THE SAME, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND COMBINED FORMULATION INCLUDING THE SAME

摘要

PURPOSE: N,N-dimethyl imidodicarbonimidic diamide butyrate is provided to ensure excellent physicochemical properties such as solubility, stability, hygroscopicity and adsorption preventing property, processibility of formulations. CONSTITUTION: A metformin butyrate is represented by chemical formula 1. The metformin butyrate has a crystal form. A melting point of the crystal form is 162°C. A method for preparing the metformin butyrate represented by chemical formula 1 comprises the steps of: reacting metformin hydrochloride represented by chemical formula 2 with base in an organic solvent to prepare metformin free base represented by chemical formula 3; and reacting the metformin free base with butyric acids.