发明名称 |
(+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF |
摘要 |
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as a method for identifying (+)-morphinans that may be therapeutically effective by determining whether the (+)-morphinan inhibits the activation of TLR9. Also provided are methods of using the (+)-morphinans comprising TLR9 antagonist activity to treat conditions such as traumatic pain, neuropathic pain, inflammatory disorders, acetaminophen toxicity, autoimmune disorders, neurodegenerative disorders, and cancer. |
申请公布号 |
WO2011009015(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
WO2010US42210 |
申请日期 |
2010.07.16 |
申请人 |
MALLINCKRODT INC.;TRAWICK, BOBBY, N.;BERBERICH, DAVID, W. |
发明人 |
TRAWICK, BOBBY, N.;BERBERICH, DAVID, W. |
分类号 |
A61K31/472;A61K31/485;A61K45/06;A61P25/00;A61P29/00;C07D217/20;C07D221/28;C07D489/00 |
主分类号 |
A61K31/472 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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