Solid-phase supports and uses thereof

摘要

The present disclosure relates to solid-phase azide supports, methods for making solid-state azide supports, and methods for capturing alkynes using the same. The present disclosure also relates to kits for solid-phase azide supports.

主权项

1. A functionalized solid support comprising the formulawherein:
X is a solid support; each Y is independently oxygen or —C(R3)(R4)—, each Z is independently oxygen or —C(R3)(R4)—, R1 and R2 are in each instance independently selected from the group consisting of n-propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, and optionally substituted aryl; R3 and R4 are in each instance independently selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, isopropyl, butyl, isobutyl, and sec-butyl; each n is an integer from 0 to 4; m is an integer from 3 to 6; and t is an integer from 3 to 6, wherein m and t are different integers.