| 摘要 |
A DRUG DELIVERY SYSTEM CONSISTING OF ONE OR MORE COMPARTMENTS AND COMPRISING A PROGESTOGENIC COMPOUND DISSOLVED IN A THERMOPLASTIC POLYETHYLENE VINYLACETATE COPOLYMER WHEREBY,—IF THE DELIVERY SYSTEM CONSISTS OF ONE COMPARTMENT, THE COMPARTMENT COMPRISES (i) A CORE OF A THERMOPLASTIC POLYETHYLENE VINYLACETATE COPOLYMER COMPRISING THE PROGESTOGENIC COMPOUND, SUCH PROGESTOGENIC COMPOUND BEING DISSOLVED IN THE POLYETHYLENE VINYLACETATE COPOLYMER UP TO A CONCENTRATION BELOW THE SATURATION LEVEL AT 25°C, AND AN ESTROGENIC COMPOUND; AND (ii) A SKIN OF A THERMOPLASTIC POLYETHYLENE VINYLACETATE COPOLYMER COVERING THE CORE, SAID SKIN BEING PERMEABLE FOR BOTH COMPOUNDS;—IF THE DELIVERY SYSTEM CONSISTS OF MORE THAN ONE COMPARTMENT, ONLY ONE COMPARTMENT COMPRISES (iii) THE PROGESTOGENIC COMPOUND, SUCH PROGESTOGENIC COMPOUND BEING DISSOLVED IN A CORE OF A THERMOPLASTIC POLYETHYLENE VINYLACETATE COPOLYMER UP TO A CONCENTRATION BELOW THE SATURATION LEVEL AT 25°C, AND AN ESTROGENIC COMPOUND; AND (iV) A SKIN OF A THERMOPLASTIC POLYETHYLENE VINYLACETATE COPOLYMER COVERING THE CORE, SAID SKIN BEING PERMEABLE FOR BOTH COMPOUNDS. |
