The present invention provides nucleosides and oligonucleotides comprising a 5' phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
申请公布号
WO2011005860(A2)
申请公布日期
2011.01.13
申请号
WO2010US41209
申请日期
2010.07.07
申请人
ALNYLAM PHARMACEUTICALS, INC.;MANOHARAN, MUTHIAH;RAJEEV, KALLANTHOTTATHIL, G.;PRHAVC, MARIJA;ZLATEV, IVAN
发明人
MANOHARAN, MUTHIAH;RAJEEV, KALLANTHOTTATHIL, G.;PRHAVC, MARIJA;ZLATEV, IVAN