NOVEL MDM2 BINDING PEPTIDES AND USES THEREOF

摘要

We have designed a peptide that is intrinsically less helical than p53 and yet has a higher affinity for MDM2 and MDMX that may be able to rescue p53 function in apoptosis by disruption of the MDM2-p53 interaction or MDMX-p53 interaction. The peptide may be used to treat cancer.