A FORMULATION OF IVABRADINE FOR TREATING THE CARDIOVASCULAR DISEASE

摘要

A sustained release composition of Ivabradine, which is capable of releasing at least 80% of active drug in 24 hours, said composition comprising Ivabradine as a base or salt thereof or suitable derivative thereof as active ingredient in therapeutically effective amount; release retarding polymers selected from the group comprising cellulose ethers in amount of about 30% to 90 % by weight; pharmaceutically acceptable excipients selected from the category of binders, diluents, lubricants, glidants, solvents, co solvents, preservatives, buffering agents, acidifiers, surfactant, channeling agents, release retardants, coating materials, colorants, and flavors. Also a process for preparation of said sustained release formulation comprising process comprising the steps of dispensing, sieving, sifting, lubrication, compression and optionally coating.