<p>The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject.</p>
申请公布号
WO2011003996(A1)
申请公布日期
2011.01.13
申请号
WO2010EP59858
申请日期
2010.07.09
申请人
F. HOFFMANN-LA ROCHE AG;DOBOSZ, MICHAEL;KLEIN, CHRISTIAN;SAM, JOHANNES;SCHEUER, WERNER
发明人
DOBOSZ, MICHAEL;KLEIN, CHRISTIAN;SAM, JOHANNES;SCHEUER, WERNER